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Beneath the Skin

T Toggle Text Size. The team inactivated genes in the mouse and looked for consequences on normal body function and disease: the focus of this study was on skin. Such a large-scale study allows us to look at genes that might not otherwise have been thought to be associated with skin development. Rather, we have taken an objective, evidence-based approach to uncover genes whose role in skin development was not known.

The team looked at genes: remarkably, mutations in one in eleven had an effect on skin development.

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The team were able to detect effects on skin that ranged from changes to fur or paw colour, to the arrangement of the individual hair follicles, to the flakiness of the skin. We also found new mutations that could help us to understand skin conditions that affect patients and perhaps help to develop new diagnostics.

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To validate the screening approach, the team looked in detail at three genes whose mutations are known to be involved in human disease. In one case, mutation in a gene called Myo5A causes effects in the mouse that mimic Griscelli syndrome.

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The team also found effects for mutations in a related gene, Myo7a , suggesting that this, also, might play a role in human skin disease. In one case, skin development in mutant mice was influenced by diet: mice fed on a high-fat diet showed less effect of the mutation than those on normal feed. These will be important in understanding human disease and would probably not be found without such a large-scale project. Such a large array of newly identified genes should improve our understanding of human skin biology and improve clinical care.

All of the information and resources generated are freely available so that other scientists can easily follow up on these new discoveries.

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The Wolfson Centre for Age-Related Diseases is a state of the art research facility that was opened in to develop strategies aimed at restoring function to the damaged nervous system. Our research is led by one of the most vibrant groupings of neuroscientists at King's College London. We use our collective expertise to evaluate and develop new therapies for pain, spinal cord injury and degenerative diseases. Researchers in the Centre are particularly interested in how stem cells interact with their local environment, or niche. An understanding of these interactions is important for developing effective cell therapies in the clinic.

A research-led university based in the heart of London, King's has nearly 23, students of whom more than 9, are graduate students from nearly countries, and some 6, employees. King's has an outstanding reputation for providing world-class teaching and cutting-edge research. In the Research Assessment Exercise for British universities, 23 departments were ranked in the top quartile of British universities; over half of our academic staff work in departments that are in the top 10 per cent in the UK in their field and can thus be classed as world leading.

King's has a particularly distinguished reputation in the humanities, law, the sciences including a wide range of health areas such as psychiatry, medicine, nursing and dentistry and social sciences including international affairs.

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